Creamy Cajun Chicken Lasagna Roll Ups to Warm Your Soul

Lasagna roll-ups with a Cajun twist offer a fiery take on the classic pasta dish.

These rolls turn the traditional layered lasagna into fun, individual servings packed with flavor.

Spicy chicken and creamy cheeses create a tasty blend that will excite your taste buds.

The mix of bold spices and familiar Italian ingredients offers something new for those who love trying different dishes.

Whether you’re cooking for family or hosting friends, this recipe is sure to impress everyone at the table.

Warm and comforting, these roll-ups are an excellent way to enjoy two favorite food styles in one meal.

How To Make Cajun Chicken Lasagna Roll Ups

Step 1: Prepare Baking Station

Warm the oven to 375°F. Coat a 9×13 baking pan with cooking spray or butter.

Step 2: Create Creamy Chicken Filling

• Ricotta cheese
• Cream cheese
• Shredded chicken
• Chopped spinach
• Diced sun-dried tomatoes
• Cajun spice blend
• Shredded cheese

Mix until ingredients are fully incorporated and smooth.

Step 3: Cook Pasta Noodles

Boil lasagna noodles until perfectly tender. Drain and lay flat on clean kitchen towels.

Step 4: Develop Spicy Alfredo Sauce

• Melt butter
• Add minced garlic
• Pour heavy cream
• Sprinkle Cajun seasoning
• Stir in grated Parmesan

Simmer until sauce thickens slightly, about 5-6 minutes.

Step 5: Layer Sauce Base

Spread a thin layer of Alfredo sauce across the bottom of the baking dish.

Step 6: Roll Lasagna Bundles

• Spread filling along one edge
• Roll tightly
• Place seam-side down in baking dish

Step 7: Cover with Sauce

Pour remaining Alfredo sauce over rolled noodles, ensuring complete coverage.

Step 8: Add Cheese Topping

Generously sprinkle additional shredded cheese across the rolls.

Step 9: Bake to Perfection

Cook uncovered for 35 minutes until edges crisp and cheese turns golden brown.

Step 10: Rest and Serve

Allow lasagna rolls to cool for 5 minutes before serving hot.

Tips To Help With Cajun Chicken Lasagna Roll Ups

• Customize Spice Levels: Adjust Cajun seasoning to match your heat preference, using more for extra kick or less for mild flavor.
• Prep Noodles Perfectly: Pat lasagna noodles dry after cooking to prevent excess moisture and ensure clean, tight roll-ups.
• Prevent Sauce Separation: Keep Alfredo sauce smooth by stirring continuously and maintaining low, steady heat during simmering.
• Make Ahead Friendly: Assemble roll-ups in advance and refrigerate, then bake when ready to serve for convenient meal planning.
• Swap Protein Options: Replace chicken with shredded turkey, pulled pork, or vegetarian alternatives like sautéed mushrooms for versatility.

How To Store And Warm Cajun Chicken Lasagna Roll Ups

• Refrigerate Leftovers: Store remaining roll-ups in an airtight container in the refrigerator for up to 3-4 days. Cover tightly with plastic wrap or lid to prevent moisture loss and maintain flavor.
• Freeze for Later: Wrap individual roll-ups in plastic wrap, then place in a freezer-safe container. Freeze for up to 2 months. Label with the date to track freshness.
• Reheat in Oven: Preheat oven to 350°F. Place roll-ups in a baking dish, cover with foil to prevent drying. Warm for 15-20 minutes until heated through. Remove foil for the last 5 minutes to crisp the cheese.
• Microwave Option: For quick reheating, place roll-ups on a microwave-safe plate. Heat in 30-second intervals, checking temperature between each interval to avoid overcooking.

Perfect Sides For Cajun Chicken Lasagna Roll Ups

• Pair Spicy Chardonnay: Select a bold, oak-aged chardonnay with slight buttery notes to complement the creamy Cajun Alfredo sauce and cut through the dish's rich flavors.
• Serve Fresh Arugula Salad: Create a zesty side salad with peppery arugula, lemon vinaigrette, and toasted pine nuts to balance the lasagna's intense spiciness and provide a crisp contrast.
• Match Crisp Pilsner Beer: Choose a light, refreshing pilsner with clean hoppy undertones that will cool down the Cajun heat and refresh the palate between bites of the creamy, spiced chicken rolls.
• Recommend Sparkling Citrus Mocktail: Mix fresh orange juice, lime, sparkling water, and a dash of cayenne to echo the Cajun seasoning while offering a bright, non-alcoholic beverage that cleanses the palate.

Ways To Change Cajun Chicken Lasagna Roll Ups

• Gluten-Free Chicken Lasagna Rolls: Replace traditional lasagna noodles with gluten-free lasagna noodles or zucchini strips for a low-carb alternative. Use gluten-free Cajun seasoning and verify all ingredients are certified gluten-free.
• Vegetarian Spinach and Mushroom Rolls: Swap chicken with roasted portobello mushrooms or plant-based chicken substitute. Keep the creamy cheese mixture and Alfredo sauce for a hearty vegetarian version that maintains the original flavor profile.
• Low-Carb Cauliflower Lasagna Rolls: Use thin cauliflower sheets or blanched cauliflower leaves instead of pasta noodles. Reduce carbohydrate content while preserving the rich, spicy Cajun chicken filling and creamy sauce.
• Dairy-Free Coconut Cream Version: Replace dairy cheeses with cashew ricotta and coconut cream. Use nutritional yeast for cheesy flavor and coconut milk in the Alfredo sauce to create a dairy-free alternative that still delivers bold Cajun flavors.

Cajun Chicken Lasagna Roll Ups FAQs

• Can I make this recipe spicier?

Add more Cajun seasoning or a dash of cayenne pepper to increase heat intensity. You can also sprinkle red pepper flakes on top before baking for extra kick.

• Is Cajun seasoning the same as other spice blends?

Cajun seasoning is unique, typically containing paprika, garlic powder, black pepper, cayenne, oregano, and thyme. It’s different from Creole or Italian seasoning blends.

• Can I use a different protein instead of chicken?

Absolutely! Shredded turkey, ground sausage, or even shrimp work great in this recipe. Just ensure the protein is cooked and seasoned before mixing into the filling.

• How do I prevent my lasagna rolls from unraveling?

Roll the noodles tightly and place them seam-side down in the baking dish. This helps them stay intact during baking. You can also use a toothpick if needed.

Why Cajun Chicken Lasagna Roll Ups Stand Out

• Elevate Family Dinner: Transform ordinary pasta night into a flavor-packed culinary adventure with these Cajun Chicken Lasagna Roll Ups that bring excitement to the table.
• Quick and Easy Preparation: Whip up this impressive dish in under an hour, making it perfect for busy weeknights when you want restaurant-quality meals without complicated techniques.
• Customizable Comfort Food: Adaptable recipe allows for easy ingredient swaps – use different proteins, adjust spice levels, or swap veggies to match your family's taste preferences while keeping the delicious core concept intact.
• Crowd-Pleasing Presentation: Create visually stunning roll-ups that look gourmet but require minimal cooking skills, guaranteed to wow dinner guests and impress even picky eaters with their beautiful layered appearance and bold Cajun flavors.

Cajun Chicken Lasagna Roll Ups Ingredient List

• Chicken: Protein base for the lasagna roll ups, works well with Cajun spices and provides hearty texture.
• Ricotta Cheese: Creamy base for filling that adds richness and binds ingredients together.
• Cream Cheese: Smooth texture enhancer that complements ricotta's consistency.

• Lasagna Noodles: Classic pasta for rolling and creating layered dish, easy to work with when cooked al dente.

• Butter: Creates rich foundation for Alfredo sauce, provides deep flavor.
• Heavy Cream: Gives smooth, luxurious texture to Alfredo sauce.
• Parmesan Cheese: Adds sharp, salty depth to sauce and enhances overall flavor.
• Shredded Cheese: Melts beautifully on top, creates golden brown crust.

• Sun-Dried Tomatoes: Adds concentrated tangy sweetness and Mediterranean flair.
• Spinach: Introduces fresh green element and additional nutrients.
• Garlic: Provides aromatic base with robust flavor profile.

• Cajun Seasoning: Signature spice mix that gives distinctive Southern-style heat and complexity.

Crave-Worthy Cajun Chicken Lasagna Roll Ups Recipe

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4.9 from 20 reviews

• Total Time: 1 hour 10 minutes
• Yield: 6 1x

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Description

Spicy Cajun Chicken Lasagna Roll Ups promise a zesty culinary adventure through Southern comfort cuisine. Melted cheese, tender chicken, and bold Cajun spices create an irresistible dish you’ll crave again and again.

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Ingredients

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Main Ingredients:

• 1 pound (454 grams) cooked chicken breast, diced (or shredded rotisserie chicken)
• 12 lasagna noodles
• 2 ½ cups (283 grams) shredded cheddar/mozzarella cheese, divided
• 1 ½ cups (340 grams) ricotta cheese
• 1 block cream cheese, softened

Filling and Flavor Ingredients:

• ⅔ cup (30 grams) frozen chopped spinach, defrosted and drained
• 4 ounces (113 grams) sun-dried tomatoes, chopped
• 1 tablespoon Cajun seasoning
• ½ cup (50 grams) grated Parmesan cheese
• 4 cloves garlic, minced

Sauce and Seasoning Ingredients:

• 4 tablespoons butter
• 1 cup (240 milliliters) heavy cream
• 1 tablespoon Cajun seasoning
• Salt and pepper, to taste

Homemade Cajun Seasoning:

• 2 tablespoons paprika
• ¾ teaspoon salt
• 2 teaspoons garlic powder
• 2 teaspoons onion powder
• 2 teaspoons chili powder
• 1 ½ teaspoons dried thyme
• 1 teaspoon dried oregano
• 1 teaspoon brown sugar
• ¾ teaspoon cayenne pepper (adjust to taste)
• ½ teaspoon black pepper

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Instructions

1. Fire up the oven to a toasty 375°F and generously coat a 9×13 baking vessel with cooking spray.
2. In a spacious mixing bowl, whip ricotta and cream cheese into a velvety smooth consistency, creating a luxurious base for the filling.
3. Incorporate sun-dried tomatoes, vibrant spinach, zesty Cajun seasoning, tender chicken, and a generous handful of shredded cheese into the creamy mixture, folding until perfectly integrated.
4. Submerge lasagna noodles in rapidly boiling water, cooking until they reach al dente perfection. Carefully drain and arrange in a single layer on a clean surface.
5. Craft the decadent Cajun Alfredo sauce by gently melting butter in a saucepan, then introducing minced garlic and allowing its aromatic essence to bloom.
6. Stream in heavy cream, sprinkle Cajun seasoning, and shower with Parmesan cheese. Allow the sauce to simmer and thicken, stirring occasionally to prevent scorching.
7. Create a silky foundation in the baking dish by spreading a thin layer of the Alfredo sauce across the bottom.
8. Transform each noodle into a delectable roll-up by spreading a generous portion of the creamy filling along one end, then rolling tightly and positioning seam-side down in the prepared dish.
9. Lavish the rolls with the remaining Cajredo Alfredo sauce, ensuring each roll is generously coated and swimming in creamy goodness.
10. Blanket the rolls with a snow of shredded cheese, creating a golden, melty exterior.
11. Slide the dish into the preheated oven and bake uncovered for 35 minutes, watching for crispy edges and a golden-brown cheese topping.
12. Allow the rolls to rest and settle for 5 minutes before serving, letting the flavors meld and the sauce slightly cool.

Notes

• Customize Cajun heat by adjusting seasoning levels for milder or spicier preferences.
• Replace chicken with shredded turkey or plant-based protein for dietary variations.
• Pat sun-dried tomatoes dry before adding to prevent excess moisture in filling.
• Ensure lasagna noodles are completely cooled to prevent filling from becoming runny when rolling.

• Prep Time: 25 minutes
• Cook Time: 45 minutes
• Category: Dinner
• Method: Baking
• Cuisine: Cajun

Nutrition

• Serving Size: 6
• Calories: 480
• Sugar: 5 g
• Sodium: 820 mg
• Fat: 28 g
• Saturated Fat: 16 g
• Unsaturated Fat: 10 g
• Trans Fat: 0 g
• Carbohydrates: 36 g
• Fiber: 2 g
• Protein: 30 g
• Cholesterol: 120 mg